程健，博士，小妲己直播
教授，博士生导师。中国生物工程学会会员，中国科学院青年创新促进会会员， Frontiers in Ecology and Evolution副主编，BioDesign Research青年编委。
科研领域及方向
[1] 人工智能与新酶设计
[2] 生物信息学
[3] 合成生物学
科研项目情况
[1] 国家自然科学基金面上项目：蛋白辅因子调控紫杉醇合成限速P450酶T5αOH催化特异性的机制研究，2026-2029
[2] 国家重点研发计划子课题：重要中药活性成分的合成生物学研究及应用示范，2023-2026
[3] 国家重点研发计划子课题：开发人工产物合成途径的智能设计平台，2020-2024
[4] 合成生物学海河实验室重大攻关项目：新抗原核酸疫苗的生物合成及工艺优化，2022-2026
[5] 国家重点研发计划课题：酶法DNA合成技术研究，2020-2021
主要学术成果
先后发表各类科研论文18篇，授权发明专利9项。发表的主要学术论文有：
1. Han X, Shao X, Liu S, Shi Z, Huang R, Chu H, Zhang H, Wang R, Li H, Liao X et al: DeepCodon: A deep learning codon-optimization model to enhance protein expression. Biodesign research 2025, 7(4):100042. (综合性期刊一区, IF:4.7)
2. Wang Q, Liu X, Zhang H, Chu H, Shi C, Zhang L, Bai J, Liu P, Li J, Zhu X*, Cheng J*, Jiang H*: Cytochrome P450 Enzyme Design by Constraining the Catalytic Pocket in a Diffusion Model. Research, 7:0413. (综合性期刊一区, IF:10.7)
3. Liu Y., Wang Q., Liu X., Cheng Jian#*, Zhang L., Chu H., Wang R., Li H., Chang H., Ahmed N., Wang Z., Liao X., Jiang H. pUGTdb: A comprehensive database of plant UDP-dependent glycosyltransferases. Molecular plant, 2023, S1674-2052(23)00003-5. (植物科学1区, IF:24.1)
4. Lu Xiaoyun#, Li Jinlong#, Li Congyu, Lou Qianqian, Peng Kai, Cai Bijun, Liu Ying, Yao Yonghong, Lu Lina, Tian Zhenyang, Ma Hongwu, Wang Wen, Cheng Jian*, Guo Xiaoxian*, Jiang Huifeng*, Ma Yanhe. Enzymatic DNA Synthesis by Engineering Terminal Deoxynucleotidyl Transferase. ACS Catalysis, 2022, 12(5): 2988-97. (化学一区, IF:13.1)
5. Cheng Jian#, Wang Xiao#, Liu Xiaonan#, Zhu Xiaoxi#, Li Zihe#, Chu Huanyu, Wang Qian, Lou QianQian, Cai Bijun, Yang Yiqun, Lu Xiaoyun, Peng Kai, Liu Dingyu, Liu Yuwan, Lu Lina, Liu Huan, Yang Ting, Ge Qijin, Shi Chengcheng, Liu Guichun, Dong Zhiwei, Xu Xun*, Wang Wen*, Jiang Huifeng*, Ma Yanhe. Chromosome-level genome of Himalayan yew provides insights into the origin and evolution of the paclitaxel biosynthetic pathway. Molecular plant, 2021, 14(7): 1199-209. (植物科学1区, IF:24.1)
6. Feng Shijing#, Liu Zhenshan#, Cheng Jian#, Li Zihe, Tian Lu, Liu Min, Yang Tuxi, Liu Yulin, Liu Yonghong, Dai He, Yang Zujun, Zhang Qing, Wang Gang, Zhang Jisen, Jiang Huifeng*, Wei Anzhi*. Zanthoxylum-specific whole genome duplication and recent activity of transposable elements in the highly repetitive paleotetraploid Z. bungeanum genome. Horticulture research, 2021, 8(1): 205. (植物科学1区, IF:8.5)
7. Cheng Jian#, Chen Jing#, Liu Xiaonan#, Li Xiangchen#, Zhang Weixiong, Dai Zhubo, Lu Lina, Zhou Xiang, Cai Jing*, Zhang Xueli*, Jiang Huifeng*, Ma Yanhe. The origin and evolution of the diosgenin biosynthetic pathway in yam. Plant Communications, 2021, 2(1): 100079. (植物科学1区, IF:11.6)
8. Liu Xiaonan#, Cheng Jian#, Zhang Guanghui#, Ding Wentao, Duan Lijin, Yang Jing, Kui Ling, Cheng Xiaozhi, Ruan Jiangxing, Fan Wei, Chen Junwen, Long Guangqiang, Zhao Yan, Cai Jing, Wang Wen, Ma Yanhe, Dong Yang, Yang Shengchao*, Jiang Huifeng*. Engineering yeast for the production of breviscapine by genomic analysis and synthetic biology approaches. Nature communications, 2018, 9(1): 448. (综合性期刊1区, IF:15.7)
9. Cheng Jian#, Guo Xiaoxian#, Cai Pengli, Cheng Xiaozhi, Piškur Jure, Ma Yanhe, Jiang Huifeng*, Gu Zhenglong*. Parallel Evolution of Chromatin Structure Underlying Metabolic Adaptation. Molecular biology and evolution, 2017, 34(11): 2870-8. (进化生物学1区, IF:5.3)
联系方式
办公地点：天津经济技术开发区第十三大街29号小妲己直播
邮政编码：300457
邮箱：[email protected]
